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<i>rahu</i> is a mutant allele of <i>Dnmt3c</i> , encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline

2017-03-29

Abstract excerpt

Transcriptional silencing by heritable cytosine-5 methylation is an ancient strategy to repress transposable elements. It was previously thought that mammals possess four DNA methyltransferase paralogs— Dnmt1 , Dnmt3a , Dnmt3b and Dnmt3l —that establish and maintain cytosine-5 methylation. Here we identify a fifth paralog, Dnmt3c , that is essential for retrotransposon methylation and repression in the mouse...

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Literature Corpus work
a0eb834d-3b24-588b-a23e-6ece0052a9c4
DOI
10.1101/121822
Open publication

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<i>rahu</i> is a mutant allele of <i>Dnmt3c</i> , encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germlineDOI 10.1101/121822
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