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Article

The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation.

The Journal of biological chemistry - 1 Sept 2024

Khudaverdyan Nelli, Lu Jiuwei, Chen Xinyi, Herle Genevieve, Song Jikui

Abstract excerpt

DNA methylation is one of the major epigenetic mechanisms crucial for gene regulation and genome stability. De novo DNA methyltransferase DNMT3C is required for silencing evolutionarily young transposons during mice spermatogenesis. Mutation of DNMT3C led to a sterility phenotype that cannot be rescued by its homologs DNMT3A and DNMT3B. However, the structural basis of DNMT3C-mediated DNA methylation remains...

Topics

DNA Methylation
DNA (Cytosine-5-)-Methyltransferases
Animals
Mice
DNA Methyltransferase 3A
Humans
DNA Methyltransferase 3B
Mutation
DNA
Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 39098534
DOI: 10.1016/j.jbc.2024.107633
PMCID: PMC11401227

Genes

DNMT3A
DNMT3B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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