Article

Dynamic evolution of <i>de novo</i> DNA methyltransferases in rodent and primate genomes

2019-09-30

Abstract excerpt

Transcriptional silencing of retrotransposons via DNA methylation is paramount for mammalian fertility and reproductive fitness. During germ cell development, most mammalian species utilize the de novo DNA methyltransferases DNMT3A and DNMT3B to establish DNA methylation patterns. However, many rodent species deploy a third enzyme, DNMT3C, to selectively methylate the promoters of young retrotransposon insertions...

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Literature Corpus work: 4ee31867-8e8c-54eb-a53e-e14335ee6616
DOI: 10.1101/786863

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