Article

ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development

2022-09-13

Abstract excerpt

<h4>ABSTRACT</h4> ZMYM2 is a transcriptional repressor whose role in development is largely unexplored. We found that Zmym2 -/- mice show embryonic lethality by E10.5. Molecular characterization of Zmym2 -/- embryos revealed two distinct defects. First, they fail to undergo DNA methylation and silencing of germline gene promoters, resulting in widespread upregulation of germline genes. Second, they fail to me...

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Literature Corpus work: 71171554-197f-55d9-a60a-8706282e6c75
DOI: 10.1101/2022.09.13.507699

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