Article

A transgenic mouse model ubiquitously overexpressing <i>Dnmt1s</i> mRNA lacks increased protein levels

2014-10-21

Abstract excerpt

Several types of cancer are characterized by global hypomethylation accompanied by regional hypermethylation and overexpression of DNA methyltransferase (cytosine-5) 1 ( Dnmt1 ). In addition to the established role of Dnmt1 as maintenance methyltransferase, it has been suggested that Dnmt1 might also methylate certain target sites de novo . We created a transgenic mouse model to investigate whether the overexpre...

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Literature Corpus work: a024c783-596a-59db-9e1a-5fc27357dad9
DOI: 10.7287/peerj.preprints.550v1

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