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Article

Induction of tumors in mice by genomic hypomethylation.

Science (New York, N.Y.) - 18 Apr 2003

Gaudet François, Hodgson J Graeme, Eden Amir, Jackson-Grusby Laurie, Dausman Jessica, Gray Joe W, Leonhardt Heinrich, Jaenisch Rudolf

Abstract excerpt

Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were...

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Identifiers

PMID: 12702876
DOI: 10.1126/science.1083558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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