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Article

CpG content affects gene silencing in mice: evidence from novel transgenes.

Genome biology - 1 Jan 2003

Chevalier-Mariette Christine, Henry Isabelle, Montfort Lucile, Capgras Suzanne, Forlani Sylvie, Muschler John, Nicolas Jean-François

Abstract excerpt

BACKGROUND: Transgenes are often engineered using regulatory elements from distantly related genomes. Although correct expression patterns are frequently achieved even in transgenic mice, inappropriate expression, especially with promoters of widely expressed genes, has been reported. DNA methylation has been implicated in the aberrant expression, but the mechanism by which the methylation of a CpG-rich sequence...

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Identifiers

PMID: 12952532
DOI: 10.1186/gb-2003-4-9-r53
PMCID: PMC193653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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