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Article

DNMT3L enables accumulation and inheritance of epimutations in transgenic Drosophila.

Scientific reports - 22 Jan 2016

Basu Amitava, Tomar Archana, Dasari Vasanthi, Mishra Rakesh Kumar, Khosla Sanjeev

Abstract excerpt

DNMT3L is an important epigenetic regulator in mammals, integrating DNA methylation and histone modification based epigenetic circuits. Here we show DNMT3L to be a part of the machinery that enables inheritance of epigenetic modifications from one generation to the next. Ectopic expression of DNMT3L in Drosophila, which lacks DNMT3L and its normal interacting partners DNMT3A and DNMT3B, lead to nuclear...

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Identifiers

PMID: 26795243
DOI: 10.1038/srep19572
PMCID: PMC4726149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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