Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.

The Journal of cell biology - 26 Feb 2007

Spada Fabio, Haemmer Andrea, Kuch David, Rothbauer Ulrich, Schermelleh Lothar, Kremmer Elisabeth, Carell Thomas, Längst Gernot, Leonhardt Heinrich

Abstract excerpt

DNA methylation plays a central role in the epigenetic regulation of gene expression in vertebrates. Genetic and biochemical data indicated that DNA methyltransferase 1 (Dnmt1) is indispensable for the maintenance of DNA methylation patterns in mice, but targeting of the DNMT1 locus in human HCT116 tumor cells had only minor effects on genomic methylation and cell viability. In this study, we identified an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methylation

Share to DNA Replication

Share to Epigenesis, Genetic

Share to Proliferating Cell Nuclear Antigen

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 17312023
DOI: 10.1083/jcb.200610062
PMCID: PMC2064015

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.PMID 17312023Read ↗

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.Semantic proximity Read ↗

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Semantic proximity Read ↗

Biological functions of DNA methyltransferase 1 require its methyltransferase activity.Semantic proximity Read ↗

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.Semantic proximity Read ↗

DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage responseSemantic proximity Read ↗

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read ↗

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.Semantic proximity Read ↗

Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases.Semantic proximity Read ↗

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.Semantic proximity Read ↗

The Role of the DNA Methyltransferase Family and the Therapeutic Potential of DNMT Inhibitors in Tumor TreatmentSemantic proximity Read ↗

DNMT1 overexpression disrupts DNA methylation homeostasis in mouse embryonic stem cellsSemantic proximity Read ↗

<i>In vivo</i> stabilization of the Dnmt1 (cytosine-5)- methyltransferase proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.