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Article

Generation of a transgenic mouse embryonic stem cell line expressing Dnmt1Y495C mutation associated with HSAN1E disorder.

Stem cell research - 1 Oct 2021

Choudhury Sumana, Mohan K Naga

Abstract excerpt

DNMT1 Y495C is the most common mutation associated with hereditary sensory and autonomic neuropathy type 1E, and dementia. Here we employed non-homologous recombination and generated a mouse embryonic stem cell line carrying a transgene expressing DNMT1 Y495C mutation in the wild-type background. The resultant cell line, Dnmt1Y495C-1 showed increased transcript levels of the Oct4 and Sox2 pluripotency markers and...

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Source

Identifiers

PMID: 34634759
DOI: 10.1016/j.scr.2021.102561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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