Article
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
Human molecular genetics - 1 May 2008
Dion Vincent, Lin Yunfu, Hubert Leroy, Waterland Robert A, Wilson John H
Abstract excerpt
Expanded CAG repeat tracts are the cause of at least a dozen neurodegenerative disorders. In humans, long CAG repeats tend to expand during transmissions from parent to offspring, leading to an earlier age of disease onset and more severe symptoms in subsequent generations. Here, we show that the maintenance DNA methyltransferase Dnmt1, which preserves the patterns of CpG methylation, plays a key role in CAG...
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