Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unstable expression of transgene is associated with the methylation of CAG promoter in the offspring from the same litter of homozygous transgenic mice.

Molecular biology reports - 1 Aug 2014

Zhou Yang, Zhang Teng, Zhang Qin-Kai, Jiang Ying, Xu Deng-Gao, Zhang Min, Shen Wei, Pan Qing-Jie

Abstract excerpt

Transgenic animals have been established for studying gene function, improving animals' production traits, and providing organ models for the exploration of human diseases. However, the stability of inheritance and transgene expression in transgenic animals has gained extensive attention. The unstable expression of transgene through DNA methyltransferase (DNMT) targeting to the methylation of transgenic DNA such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to DNA Methyltransferase 3B

Share to Green Fluorescent Proteins

Share to Methyltransferases

Share to Transgenes

Source

Identifiers

PMID: 24804614
DOI: 10.1007/s11033-014-3385-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unstable expression of transgene is associated with the methylation of CAG promoter in the offspring from the same litter of homozygous transgenic mice.PMID 24804614Read ↗

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.Semantic proximity Read ↗

A transgenic mouse model ubiquitously overexpressing <i>Dnmt1s</i> mRNA lacks increased protein levelsSemantic proximity Read ↗

An efficient strategy for generation of transgenic mice by lentiviral transduction of male germline stem cells in vivoSemantic proximity Read ↗

CpG content affects gene silencing in mice: evidence from novel transgenes.Semantic proximity Read ↗

Embryo culture-based generation of enhanced green fluorescent protein-transgenic mice.Semantic proximity Read ↗

Transgenic Mice and Pluripotent Stem Cells Express EGFP under the Control of miR-302 PromoterSemantic proximity Read ↗

Overexpression of human-derived DNMT3A induced intergenerational inheritance of DNA methylation and gene expression variations in rat brain and testis.Semantic proximity Read ↗

Distal transgene insertion affects CpG island maintenance during differentiation.Semantic proximity Read ↗

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.Semantic proximity Read ↗

Stable long-term germ-line transmission of transgene integration sites in mice.Semantic proximity Read ↗

Analysis of the transgene insertion pattern in a transgenic mouse strain using long-read sequencing.Semantic proximity Read ↗

Transgenic production of the mouse in vitro- and in vivo-derived embryos: Effect on the methylation pattern of OCT4 promoter, expression levels of Dnmts, and Oct4Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.