Article

Multi‑omics profiling reveals shared blood-brain barrier stress signatures and disease-specific vascular remodelingin capillary cerebral amyloid angiopathy and GRN-associated frontotemporal dementia

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Frontotemporal dementia caused by progranulin mutations (FTD-GRN) and capillary cerebral amyloid angiopathy (capCAA) are neurodegenerative disorders marked by protein aggregation, neuronal loss, and neuroinflammation. Although their etiologies differ, both exhibit blood–brain barrier (BBB) perturbations, implicating vascular dysfunction as contributing to neuropathology. Here, we aimed...

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Literature Corpus work: 1e12edde-c02c-506f-af73-ff5c384206f4
DOI: 10.21203/rs.3.rs-9854878/v1

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Multi‑omics profiling reveals shared blood-brain barrier stress signatures and disease-specific vascular remodelingin capillary cerebral amyloid angiopathy and GRN-associated frontotemporal dementiaDOI 10.21203/rs.3.rs-9854878/v1Read

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