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Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s disease

2023-02-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> In this study, we explore the role of oxidative stress produced by NOX2-containing NADPH oxidase as a molecular mechanism causing capillary stalling and cerebral blood flow deficits in the APP/PS1 mouse model of AD. <h4>METHODS</h4> We inhibited NOX2 in APP/PS1 mice by administering a 10 mg/kg dose of the peptide inhibitor gp91-ds-tat i.p., for two weeks. We used in vivo...

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Literature Corpus work
267849a9-845e-5a31-b507-aff18ecbf3ec
DOI
10.1101/2023.02.15.528710
Open publication

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