Article

Design of solubly expressed miniaturized SMART MHCs

2025-03-14

Abstract excerpt

The precise recognition of specific peptide-MHC (pMHC) complexes by T-cell receptors (TCRs) plays a key role in infectious disease, cancer and autoimmunity. A critical step in many immunobiological studies is the identification of T-cells expressing TCRs specific to a given pMHC antigen. However, the intrinsic instability of empty class-I MHCs limits their soluble expression in Escherichia coli ( E. coli ) and m...

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Literature Corpus work: 9ff9332e-22eb-5143-bd11-d07777cb98d3
DOI: 10.1101/2025.03.14.643101

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