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Article

Directed evolution of soluble single-chain human class II MHC molecules.

Journal of molecular biology - 25 Jun 2004

Esteban Olga, Zhao Huimin

Abstract excerpt

Major histocompatibility complex (MHC) class II molecules are membrane-anchored heterodimers that present antigenic peptides to T cells. Expression of these molecules in soluble form has met limited success, presumably due to their large size, heterodimeric structure and the presence of multiple disulfide bonds. Here we have used directed evolution and yeast surface display to engineer soluble single-chain human...

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Identifiers

PMID: 15184024
DOI: 10.1016/j.jmb.2004.04.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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