Article

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

2023-03-18

Abstract excerpt

The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, or glycolipids presents a fundamental challenge for identifying disease-relevant antigens and antigen-specific T cell receptors (TCRs), hindering the development of autologous therapeutics. Here, we leverage the positive allosteric coupling betwee...

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Literature Corpus work: 3cec1f70-1990-596c-8f32-63fa3236d408
DOI: 10.1101/2023.03.18.533266

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