Article

Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis

2022-11-18

Abstract excerpt

<title>Abstract</title> CD8 + cytotoxic T cell responses against viral infection represent a major element of the adaptive immune response. We describe the development of a peptide antigen – major histompatibility complex (pMHC) library representing the full SARS-CoV-2 viral proteome, and comprised of 634 pMHC multimers representing the A*02.01, A*24.02, and B*07.02 HLA alleles, as well as specific antigens as...

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Literature Corpus work: 51cfe63e-5cb3-5386-a0d5-844b4212882e
DOI: 10.21203/rs.3.rs-1090664/v1

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