Article

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies

2022-07-16

Abstract excerpt

T-cell receptor-mimetic antibodies (TCRms) targeting disease-associated peptides presented by Major Histocompatibility Complexes (pMHCs) are set to become a major new drug modality. However, we lack a general understanding of how TCRms engage pMHC targets, which is crucial for predicting their specificity and safety. Several new structures of TCRm:pMHC complexes have become available in the past year, providing su...

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Literature Corpus work: 00084fe5-e154-56e9-8303-fecdb985b5a5
DOI: 10.1101/2022.07.15.500208

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