Article

A miniaturized MR1 metabolite display system with native-like protein features

2026-04-15

Abstract excerpt

Major histocompatibility complex class I–related protein 1 (MR1) presents metabolite-derived antigens to mucosal-associated invariant T (MAIT) cells and other MR1-restricted T cells, playing a critical role in immune surveillance during infection and disease. Biochemical and structural studies of MR1 have been limited by the intrinsic instability of the molecule, which requires both ligand binding and association...

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Literature Corpus work: 083cd543-6ccb-5670-99dc-8eaf82729983
DOI: 10.64898/2026.04.13.718121

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