Article

Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress

2025-09-13

Abstract excerpt

Chemical damage to ribosomal RNA (rRNA) during oxidative or inflammatory stress can impact protein synthesis. Human cells were exposed to a H 2 O 2 titration series to induce oxidative stress or to tumor necrosis factor-α to induce inflammation over a time course followed by RNA direct nanopore sequencing of cytosolic and mitochondrial rRNAs. The guanosine (G) oxidation sites and deamination of adenosine to inos...

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Literature Corpus work: 9ff31abe-f3d9-59d8-b645-d4f0441b2a42
DOI: 10.1101/2025.09.11.675630

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