Structure of the human 80S ribosome at 1.9 Å resolution – the molecular role of chemical modifications and ions in RNA

Abstract excerpt

<h4>Summary</h4> The ribosomal RNA of the human protein synthesis machinery comprises numerous chemical modifications that are introduced during ribosome biogenesis. We present the 1.9 Å resolution cryo-EM structure of the 80S human ribosome resolving numerous new rRNA modifications and functionally important ions such as Zn 2+ , K + and Mg 2+ including their associated individual water molecules. 2’-O-methyla...

Topics

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• Cell Line, Transformed
• Cryoelectron Microscopy
• Dyskeratosis Congenita
• Protein Biosynthesis
• Ribosomes
• RNA
• RNA Processing, Post-Transcriptional
• RNA, Ribosomal, 28S

Identifiers and source

Literature Corpus work

66b0074b-ebae-5792-9417-b00b6fbaee3c

DOI

10.1101/2023.11.23.568509