Article
Oxidation and alkylation stresses activate ribosome-quality control.
Nature communications - 9 Dec 2019
Yan Liewei L, Simms Carrie L, McLoughlin Fionn, Vierstra Richard D, Zaher Hani S
Abstract excerpt
Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties within RNA. It is, however, unclear whether organisms have evolved general mechanism(s) to deal with this damage. Here we show that the mRNA-surveillance pathway of no-go decay and the associated ribosome-quality control are activated in response to nucleobase alkylation and oxidation. Our findings reveal that these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.