Article

Structural Basis of T Cell Toxicity Induced by Tigecycline Binding to the Mitochondrial Ribosome

2024-07-17

Abstract excerpt

<title>Abstract</title> <p>Tetracyclines are essential bacterial protein synthesis inhibitors under continual development to combat antibiotic resistance yet suffer from unwanted side effects. Therefore, next-generation drugs should better discriminate between prokaryotic and eukaryotic ribosomes to ensure host cells remain unaffected by treatment. Mitoribosomes - responsible for generating oxidative phosphorylat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b724d873-47c2-51d6-9215-1eb0f3cbe036
DOI: 10.21203/rs.3.rs-4671643/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Basis of T Cell Toxicity Induced by Tigecycline Binding to the Mitochondrial RibosomeDOI 10.21203/rs.3.rs-4671643/v1Read

The killing of human gut commensal <i>E. coli</i> ED1a by tetracycline is associated with severe ribosome dysfunctionSemantic proximity Read

Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome.Semantic proximity Read

Tetracyclines Modify Translation By Targeting Key Human rRNA SubstructuresSemantic proximity Read

Tigecycline - how powerful is it in the fight against antibiotic-resistant bacteria?Semantic proximity Read

Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stressSemantic proximity Read

Genetic ablation of the mitochondrial ribosome in <i>Plasmodium falciparum</i> sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functionsSemantic proximity Read

Structure–function insights reveal the human ribosome as a cancer target for antibioticsSemantic proximity Read

Investigating the Inhibition of FTSJ1 a Tryptophan tRNA-Specific 2′-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTRSemantic proximity Read

Conformational diversity of collided ribosomes determines stress signalingSemantic proximity Read

Principles of Chemical Biology: From Antibiotic Resistance to RNA-Targeted Therapy via Autoxidation and Lipid Droplets.Semantic proximity Read

Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs <i>in vivo</i> to control <i>Mycobacterium tuberculosis</i> growthSemantic proximity Read

Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survivalSemantic proximity Read