Article

CO <sub>2</sub> protects cells from iron-Fenton oxidative DNA damage in E. coli and humans

2024-08-26

Abstract excerpt

Whereas hydroxyl radical is commonly named as the Fenton product responsible for DNA and RNA damage in cells, here we demonstrate that the cellular reaction generates carbonate radical anion due to physiological levels of bicarbonate. Analysis of the metabolome, transcriptome and, in human cells, the nuclear genome shows a consistent buffering of H 2 O 2 -induced oxidative stress leading to one common pathway, n...

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Identifiers and source

Literature Corpus work: 9d4c0a3b-31d8-58a4-9783-c1371e907c84
DOI: 10.1101/2024.08.26.609766

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