Article

Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitis

2025-04-10

Abstract excerpt

<title>Abstract</title> Microglia are resident innate immune cells in the central nervous system (CNS) that provides anti-microbial protection but also promote neuroinflammation. BRD4 is a chromatin reader that binds to acetylated histones and directs transcription of numerous genes. However, it is unknown whether and how BRD4 regulates microglia function. We addressed the role of microglia and BRD4 in a neuro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fee2435-0887-5aa2-b724-05584b30d723
DOI: 10.21203/rs.3.rs-5271234/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitisDOI 10.21203/rs.3.rs-5271234/v1Read

BRD4 expression in microglia supports recruitment of T cells into the CNS and exacerbates EAESemantic proximity Read

Analyzing microglial phenotypes across neuropathologies: a practical guide.Semantic proximity Read

CD11c + CD88 + CD317 + myeloid cells are critical mediators of persistent CNS autoimmunitySemantic proximity Read

Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelinationSemantic proximity Read

Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibitionSemantic proximity Read

Transcriptional control of microglia phenotypes in health and disease.Semantic proximity Read

Deciphering microglia phenotypes in health and disease.Semantic proximity Read

Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human NeurodegenerationSemantic proximity Read

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers ProtectionSemantic proximity Read

The BET inhibitor attenuates the inflammatory response and cell migration in human microglial HMC3 cell lineSemantic proximity Read

Dicer deficiency in microglia leads to accelerated demyelination and failed remyelinationSemantic proximity Read

Microglial responses to peripheral type 1 interferonSemantic proximity Read