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Article

The BET inhibitor attenuates the inflammatory response and cell migration in human microglial HMC3 cell line

23 Apr 2021

Abstract excerpt

Microglia, resident macrophages of the brain that act as primary immune cells, play essential roles in innate immunity and neuroinflammatory pathologies. Microglial cells are rapidly activated in response to infection and inflammation/injury, associated with the expression of proinflammatory genes and secretion of cytokines. The bromodomain and extra-terminal (BET) inhibitor JQ1 has been shown to be an epigenetic...

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PMID: 33893325
DOI: 10.1038/s41598-021-87828-1

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