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Article

Microglial responses to peripheral type 1 interferon

12 Nov 2020

Abstract excerpt

BACKGROUND: Interferon α (IFNα) is a cytokine whose production is increased endogenously in response to viral infection and in autoimmune diseases such as systemic lupus erythematosus (SLE). An elevated IFNα signature has been associated with clinically observed neuro-behavioural deficits such as mild cognitive impairment, fatigue, depression and psychosis in these diseases. However, the mechanisms underlying...

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PMID: 33183319
DOI: 10.1186/s12974-020-02003-z

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