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BRD4 expression in microglia supports recruitment of T cells into the CNS and exacerbates EAE

2024-09-15

Abstract excerpt

In EAE, a mouse model of multiple sclerosis, immunization with MOG autoantigen results in the generation of Th1/Th17 T cells in the periphery. MOG-specific T cells then invade into the central nervous system (CNS), resulting in neuronal demyelination. Microglia, innate immune cells in the CNS are known to regulate various neuronal diseases. However, the role of microglia in EAE has remained elusive. BRD4 is a BET...

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Identifiers and source

Literature Corpus work
7a4b31ba-d860-53f5-b7b3-c91c9d085b67
DOI
10.1101/2024.09.13.612948
Open publication

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