Article

Structure-based learning to model complex protein-DNA interactions and transcription-factor co-operativity in <i>cis</i> -regulatory elements

2022-04-17

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factor (TF) binding is a key component of genomic regulation. There are numerous high-throughput experimental methods to characterize TF-DNA binding specificities. Their application, however, is both laborious and expensive, which makes profiling all TFs challenging. For instance, the binding preferences of ~25% human TFs remain unknown; they neither have been determined experiment...

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Literature Corpus work: 9fb4bcef-e87b-5b0f-9643-912aaba7ea6a
DOI: 10.1101/2022.04.17.488557

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