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Article

Learning probabilistic protein-DNA recognition codes from DNA-binding specificities using structural mappings.

Genome research - 27 Sept 2022

Wetzel Joshua L, Zhang Kaiqian, Singh Mona

Abstract excerpt

Knowledge of how proteins interact with DNA is essential for understanding gene regulation. Although DNA-binding specificities for thousands of transcription factors (TFs) have been determined, the specific amino acid-base interactions comprising their structural interfaces are largely unknown. This lack of resolution hampers attempts to leverage these data in order to predict specificities for uncharacterized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36123148
DOI: 10.1101/gr.276606.122
PMCID: PMC9528988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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