Article

Learning probabilistic protein-DNA recognition codes from DNA-binding specificities using structural mappings

2022-02-01

Abstract excerpt

Knowledge of how proteins interact with DNA is essential for understanding gene regulation. While DNA-binding specificities for thousands of transcription factors (TFs) have been determined, the specific amino acid-base interactions comprising their structural interfaces are largely unknown. This lack of resolution hampers attempts to leverage these data in order to predict specificities for uncharacterized TFs or...

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Literature Corpus work: 9ba29240-e226-5e02-8952-d6bba1f4465c
DOI: 10.1101/2022.01.31.477772

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