Article

Spermidine/spermine N1-acetyltransferase controls tissue-specific regulatory T cell function in chronic inflammation

2024-03-28

Abstract excerpt

<h4>Summary</h4> Regulatory T cells (T regs ) are a critical immune component guarding against excessive inflammatory responses. During chronic inflammation, T regs fail to control effector T cell responses. The causes of T reg dysfunction in these diseases are poorly characterized and therapies are aimed at blocking aberrant effector responses rather than rescuing T reg function. Here we utilized single-cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fab0899-049b-5c08-8670-3c4fe20f2c5b
DOI: 10.1101/2024.03.25.586519

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spermidine/spermine N1-acetyltransferase controls tissue-specific regulatory T cell function in chronic inflammationDOI 10.1101/2024.03.25.586519Read

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissueSemantic proximity Read

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppressionSemantic proximity Read

A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.Semantic proximity Read

Single-cell-based evidence for GLS1 inhibitor as a bona fide senolytic agent in vivoSemantic proximity Read

Integration of genetic and epigenetic data pinpoints autoimmune specific remodelling of enhancer landscape in CD4+ T cellsSemantic proximity Read

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammationSemantic proximity Read

The common <i>TMEM173 HAQ, AQ</i> alleles rescue CD4 T cellpenia, restore T-regs, and prevent <i>SAVI (N153S)</i> inflammatory disease in miceSemantic proximity Read

RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammationSemantic proximity Read

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitisSemantic proximity Read

Deciphering the Regulatory Landscape of <i>γδ</i> T Cell Development by Single-Cell RNA-SequencingSemantic proximity Read

MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitisSemantic proximity Read

Integrative epigenomic and transcriptomic profiling reveals dysregulated T cell regulatory networks in Stage 3 Type 1 diabetesSemantic proximity Read