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The common <i>TMEM173 HAQ, AQ</i> alleles rescue CD4 T cellpenia, restore T-regs, and prevent <i>SAVI (N153S)</i> inflammatory disease in mice

2023-10-07

Abstract excerpt

The significance of STING (encoded by the TMEM173 gene) in tissue inflammation and cancer immunotherapy has been increasingly recognized. Intriguingly, common human TMEM173 alleles R71H-G230A-R293Q ( HAQ) and G230A-R293Q ( AQ ) are carried by ∼60% of East Asians and ∼40% of Africans, respectively. Here, we examine the modulatory effects of HAQ, AQ alleles on STING-associated vasculopathy with onset in infancy...

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Literature Corpus work
83ce19eb-315c-54ae-a809-86e708efed4d
DOI
10.1101/2023.10.05.561109
Open publication

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