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Article

Integrative epigenomic and transcriptomic profiling reveals dysregulated T cell regulatory networks in Stage 3 Type 1 diabetes

2026-04-07

Abstract excerpt

<title>Abstract</title> <p>Aims/hypothesis. Type 1 diabetes (T1D) is driven by destruction of the pancreatic beta cells by autoreactive T cells, which occurs as a result of failed immune tolerance. The disruptions to the molecular mechanisms that maintain this tolerance are complex, and the balance between conventional CD4⁺ T cells (Tconv) and regulatory T cells (Treg) in T1D remain poorly defined. We hypothesis...

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Literature Corpus work
fd75b7b4-910b-5965-ba04-313f6a54816b
DOI
10.21203/rs.3.rs-9142251/v1
Open publication

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Integrative epigenomic and transcriptomic profiling reveals dysregulated T cell regulatory networks in Stage 3 Type 1 diabetesDOI 10.21203/rs.3.rs-9142251/v1
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