Article

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

2019-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Regulatory T cells (T regs ) can impair anti-tumor immune responses and are associated with poor prognosis in multiple cancer types. T regs in human tumors span diverse transcriptional states distinct from those of peripheral T regs , but their contribution to tumor development remains unknown. Here, we used single cell RNA-Seq to longitudinally profile conventional CD4 + T cells (T conv )...

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Literature Corpus work: e8c9c923-ecda-5eb0-9744-dc04de1f4cd7
DOI: 10.1101/512905

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