Article

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue

2024-10-15

Abstract excerpt

<h4>Objectives</h4> Interleukin (IL)-17A is a key driver of Spondyloarthritis (SpA) joint pathology. We aimed to identify its cellular source in synovial tissue from patients with two forms of SpA namely Axial SpA (AxSpA) and Psoriatic arthritis (PsA). <h4>Methods</h4> Synovial tissue from patients with SpA was profiled using single-cell RNA sequencing (scRNA-seq: AxSpA, n=5 and PsA, n=6) or spatial RNA profilin...

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Literature Corpus work: cac93736-aef7-593e-b650-2b26ed956cdd
DOI: 10.1101/2024.10.11.617865

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