Article

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

2022-03-23

Abstract excerpt

Interleukin IL-17 cytokines are central regulators of mucosal homeostasis and disease. In mouse models of colonic tissue injury, IL-17A promotes epithelial barrier functions and restricts local inflammation. Here, we report that IL-17A production by the diverse T lymphocyte subsets is dynamically regulated at different stages of colitis pathogenesis. During the onset and peak of the disease, Tγδ17 cells are the ma...

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Identifiers and source

Literature Corpus work: 12a13d7a-a30b-5286-931c-608508e66a42
DOI: 10.1101/2022.03.21.485192

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