Article

Single-cell-based evidence for GLS1 inhibitor as a bona fide senolytic agent in vivo

2025-07-23

Abstract excerpt

A plethora of senolytic compounds and technologies have been identified. However, the efficacy of these treatments in eliminating senescent cells and the suppression of chronic inflammation remains to be substantiated in vivo. Here, we employ single-cell RNA sequencing and find the selective elimination of highly inflammatory fibroblasts, endothelial cells in the lung, and proximal tubule cells in the kidney from...

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Identifiers and source

Literature Corpus work: a822b284-9354-5d0a-b204-76514fb0bd97
DOI: 10.1101/2025.07.22.666220

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