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Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis

16 Feb 2023

Abstract excerpt

Abstract T helper 17 (Th17) cells are a subset of CD4+ T helper cells involved in the inflammatory response in autoimmunity. Th17 cells secrete Th17 specific cytokines, such as IL-17A and IL17-F, which are governed by the master transcription factor RoRγt. However, the epigenetic mechanism regulating Th17 cell function is still not fully understood. Here, we reveal that deletion of RNA 5-methylcytosine (m5C)...

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PMID: 36792629
DOI: 10.1038/s41467-023-36595-w

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