Article

Stiffness Drives Endothelial Senescence and Inflammation in Aging and Doxorubicin-Induced Vascular Dysfunction

2026-02-02

Abstract excerpt

Age-related arterial stiffening affects over ∼ 60% of elderly individuals and is a major independent risk factor for cardiovascular mortality. Similarly, doxorubicin-induced cardiotoxicity affects up to ∼ 48% of cancer patients, limiting therapeutic options. Here, we demonstrate that vascular stiffness mechanically amplifies endothelial senescence phenotypes, identifying the extracellular matrix as a potential the...

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Literature Corpus work: a8fb9eb4-a3b7-51cc-b337-d0933cd92b62
DOI: 10.64898/2026.01.30.702284

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