Article

Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells

2023-08-19

Abstract excerpt

Cell culture on soft matrix, either in 2D and 3D, preserves the characteristics of progenitors. However, the mechanism by which the mechanical microenvironment determines progenitor phenotype, and its relevance to human biology, remains poorly described. Here we designed multi-well hydrogel plates with a high degree of physico-chemical uniformity to reliably address the molecular mechanism underlying cell state mo...

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Literature Corpus work: 8506bf2f-6988-5d6f-8d4d-8b8fc8531a04
DOI: 10.1101/2023.08.18.552093

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