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Mature tumoroids recapitulate clinically relevant drug response through extended 3D culture in PDAC

2026-04-07

Abstract excerpt

<h4>Background</h4> Drug responses in pancreatic ductal adenocarcinoma (PDAC) vary sharply across in vitro culture formats, but most 2D–3D comparisons conflate microenvironmental cues with time-dependent cellular adaptation. As a result, conventional assays frequently overestimate drug efficacy and poorly reflect clinical pharmacology. <h4>Main findings</h4> We profiled MiaPaCa-2, PANC-1, and CFPAC-1 grown in...

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Literature Corpus work
146d8ebe-c1f9-5a65-b15a-d23f2c5f6d5f
DOI
10.64898/2026.04.04.716464
Open publication

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Mature tumoroids recapitulate clinically relevant drug response through extended 3D culture in PDACDOI 10.64898/2026.04.04.716464
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