Article

Principles and functional consequences of plasmid chromatinization in mammalian cells

2025-05-30

Abstract excerpt

Plasmids have fundamentally transformed how we resolve regulatory grammar across the tree of life. However, although chromatin plays an integral role in regulating the function of regulatory elements along the nuclear genome, our understanding of how, or whether, similar chromatin structures form on plasmids transfected into mammalian cells remains limited. We demonstrate that plasmid single-molecule chromatin fib...

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Literature Corpus work: e211df1b-6c59-5b87-89ee-fc6a553f8ecf
DOI: 10.1101/2025.05.27.656122

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