Promoter shape varies across populations and affects promoter evolution and expression noise.

doi:10.1038/ng.3791

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Article

Promoter shape varies across populations and affects promoter evolution and expression noise.

Nature genetics - 1 Apr 2017

Schor Ignacio E, Degner Jacob F, Harnett Dermot, Cannavò Enrico, Casale Francesco P, Shim Heejung, Garfield David A, Birney Ewan, Stephens Matthew, Stegle Oliver, Furlong Eileen E M

Abstract excerpt

Animal promoters initiate transcription either at precise positions (narrow promoters) or dispersed regions (broad promoters), a distinction referred to as promoter shape. Although highly conserved, the functional properties of promoters with different shapes and the genetic basis of their evolution remain unclear. Here we used natural genetic variation across a panel of 81 Drosophila lines to measure changes in...

Topics

Animals
Biological Evolution
Drosophila
Genetic Variation
Noise
Promoter Regions, Genetic
Transcription Initiation Site
Transcription, Genetic

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Open in PubMed

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PMID: 28191888
DOI: 10.1038/ng.3791

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