FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

doi:10.1038/ncomms9613

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Nature communications - 12 Oct 2015

Helliwell Stephen B, Karkare Shantanu, Bergdoll Marc, Rahier Alain, Leighton-Davis Juliet R, Fioretto Celine, Aust Thomas, Filipuzzi Ireos, Frederiksen Mathias, Gounarides John, Hoepfner Dominic, Hofmann Andreas, Imbert Pierre-Eloi, Jeker Rolf, Knochenmuss Richard, Krastel Philipp, Margerit Anais, Memmert Klaus, Miault Charlotte V, Rao Movva N, Muller Alban, Naegeli Hans-Ulrich, Oberer Lukas, Prindle Vivian, Riedl Ralph, Schuierer Sven, Sexton Jessica A, Tao Jianshi, Wagner Trixie, Yin Hong, Zhang Juan, Roggo Silvio, Reinker Stefan, Parker Christian N

Abstract excerpt

FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P) dependent steroid dehydrogenase-like)), an essential enzyme in the ergosterol/cholesterol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Hydroxysteroid Dehydrogenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antifungal Agents

Share to Candida albicans

Share to Cholesterol

Share to Drug Resistance, Fungal

Share to Ergosterol

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26456460
DOI: 10.1038/ncomms9613
PMCID: PMC4633953

Genes

NSDHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.PMID 26456460Read ↗

The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.Semantic proximity Read ↗

A yeast-based assay identifies drugs active against human mitochondrial disorders.Semantic proximity Read ↗

Identification of Potential New Genes Related to the SREBP Pathway in Xanthophyllomyces dendrorhous.Semantic proximity Read ↗

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive speciesSemantic proximity Read ↗

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus speciesSemantic proximity Read ↗

Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.Semantic proximity Read ↗

Yeast as a tool to identify anti-aging compounds.Semantic proximity Read ↗

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDGSemantic proximity Read ↗

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment LibrarySemantic proximity Read ↗

Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.Semantic proximity Read ↗

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.Semantic proximity Read ↗

Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.