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Emerging Roles of Aldehyde Dehydrogenase Isoforms in Anti-cancer Therapy Resistance

1 Mar 2022

Abstract excerpt

Aldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes often upregulated in cancer cells and associated with therapeutic resistance. In humans, the ALDH family comprises 19 isoenzymes active in the majority of mammalian tissues. Each ALDH isoform has a specific differential expression pattern and most of them have individual functional roles in cancer. ALDHs are overexpressed in subpopulations of...

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PMID: 35299840
DOI: 10.3389/fmed.2022.795762

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