Article

Mecp2 deletion results in profound alterations of developmental and adult functional connectivity

2021-10-28

Abstract excerpt

As a regressive neurodevelopmental disorder with a well-established genetic cause, Rett Syndrome and its Mecp2 loss-of-function mouse model provide an excellent opportunity to define potentially translatable functional signatures of disease progression, as well as offer insight into Mecp2 ’s role in functional circuit development. Thus, we applied optical fluorescence imaging to assess mesoscale calcium function...

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Literature Corpus work: 394f978a-9a0a-5558-904b-3a3334fdbbef
DOI: 10.1101/2021.10.28.466323

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