Article

Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires MECP2

2019-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The neurodevelopmental disorder Rett syndrome is caused by mutations in the gene Mecp2 . Misexpression of the protein MECP2 is thought to contribute to neuropathology by causing dysregulation of plasticity. Female heterozygous Mecp2 mutants ( Mecp2 het ) failed to acquire a learned maternal retrieval behavior when exposed to pups, an effect linked to disruption of parvalbumin-expressing inhib...

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Literature Corpus work: 5136759d-fd36-5736-8cbc-9c43fea3d58f
DOI: 10.1101/655035

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