Article

Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome

2025-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Rett Syndrome, a neurodevelopmental disorder caused by loss-of-function mutations in the MECP2 gene, is characterized by severe motor, cognitive and emotional impairments. Some of the deficits may result from changes in cortical connections, especially downstream projections of the prefrontal cortex, which may also be targets of restoration following rearing conditions such as environmental enr...

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Literature Corpus work: 28285478-52f8-50e1-8f73-e99c12119ee6
DOI: 10.1101/2025.02.10.637474

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